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  • With Mayo Clinic emeritus internist

    Kenneth G. Berge, M.D.

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Mayo Clinic Health Manager

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Question

Melatonin side effects: What are the risks?

I'm considering taking melatonin to help me sleep. What do I need to know about melatonin side effects?

Answer

from Kenneth G. Berge, M.D.

The hormone melatonin helps control your natural sleep-wake cycle. In fact, natural levels of melatonin in the blood are highest just before bedtime. If you're struggling with insomnia, melatonin supplements may help you fall asleep or stay asleep. However, there are no guarantees. Most studies show melatonin to be only minimally effective for insomnia. Melatonin may play a stronger role in fighting jet lag. Melatonin side effects may include daytime sleepiness, dizziness, headaches and abdominal discomfort. Confusion, sleepwalking or nightmares also are possible. Some studies suggest that melatonin increases the risk of seizures, but others disagree. Melatonin may interact with various medications. The optimal dose of melatonin isn't certain, and the long-term effects are unknown. Talk to your doctor before taking melatonin, especially if you have any underlying health conditions. If you decide to take melatonin, make sure the supplements are manufactured in a lab, not derived from animals.

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