Mayo Clinic Health Manager

Get free personalized health guidance for you and your family.

Get Started

Free

E-Newsletter

Subscribe to receive the latest updates on health topics. View sample

Definition

By Mayo Clinic staff

Nicotine dependence is an addiction to tobacco products caused by the drug nicotine. Smoke from cigarettes, cigars and pipes contains thousands of chemicals, including nicotine. Smokeless tobacco also contains nicotine. Nicotine dependence means you can't stop using the substance, even though it's causing you harm.

Nicotine produces physical and mood-altering effects in your brain that are temporarily pleasing. These effects spur your continued use of tobacco and lead to dependence. At the same time, quitting tobacco use causes withdrawal symptoms, including irritability and anxiety.

Nicotine dependence brings a host of health problems. While it's the nicotine in tobacco that keeps you hooked, the toxic effects come mainly from other substances in tobacco. Smokers have significantly higher rates of heart disease, stroke and cancer.

Symptoms
References
  1. Nicotine. NIDA for Teens. http://www.teens.drugabuse.gov/drnida/drnida_nic1.asp. Accessed Oct. 20, 2008.
  2. Cigarette smoking. American Cancer Society. http://www.cancer.org/docroot/PED/content/PED_10_12X_Cigarette_Smoking.asp?sitearea=PED. Accessed Oct. 20, 2008.
  3. Benowitz NL. Clinical pharmacology of nicotine: Implications for understanding, preventing, and treating tobacco addiction. Clinical Pharmacology & Therapeutics. 2008;83(4):531-541.
  4. Smoking 101 fact sheet. American Lung Association. http://www.lungusa.org/site/pp.asp?c=dvLUK9O0E&b=39853. Accessed Oct. 20, 2008.
  5. Hatsukami DK, et al. Tobacco addiction. The Lancet. 2008;371:2027-2038.
  6. Burke MV, et al. Treatment of tobacco dependence. Mayo Clinic Proceedings. 2008;83(4):479-484.
  7. Nides M. Update on pharmacologic options for smoking cessation treatment. The American Journal of Medicine. 2008;121(4A):S20-S31.
  8. Executive summary. In: Treating tobacco use and dependence: 2008 update. Rockville, Md.: Agency for Healthcare Research and Quality. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat2.section.28189. Accessed Oct. 14, 2008.
  9. Guide to quitting smoking. American Cancer Society. http://www.cancer.org/docroot/PED/content/PED_10_13X_Guide_for_Quitting_Smoking.asp?sitearea=PED. Accessed Oct. 20, 2008.
  10. Le Foll B, et al. Treatment of tobacco dependence: Integrating recent progress into practice. Canadian Medical Association Journal. 2007;177(11):1373-1380.
  11. Benowitz NL. Neurobiology of nicotine addiction: Implications of smoking cessation treatment. The American Journal of Medicine. 2008;121(4A):S3-S10.
  12. Woodward K. Quit before kids reach third grade. Fred Hutchinson Cancer Research Center. http://www.fhcrc.org/about/pubs/center_news/2003/may15/sart1.html?&printfriendly=yes. Accessed Oct. 22, 2008.
  13. Berrettini W. Nicotine addiction. The American Journal of Psychiatry. 2008;165(9):1089-1092.
  14. Clinical interventions for tobacco use and dependence. In: Treating tobacco use and dependence: 2008 update. Rockville, Md.: Agency for Healthcare Research and Quality. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat2.section.28251. Accessed Oct. 20, 2008.
  15. Smoking and cardiovascular disease risk. Washington, DC: American Heart Association.
  16. Kuehn BM. Personalized care may help smokers quit. Journal of the American Medical Association. 2007. 298(21): 2472. 
  17. Niaura R. Nonpharmocologic therapy for smoking cessation: Characteristics and efficacy of current approaches. The American Journal of Medicine. 2008;121(4A):S11-S19.
  18. Online guide to quitting: Managing cravings. Smokefree.gov. htttp://www.smokefree.gov/quit-smoking/managing_cravings.html. Accessed Oct. 20, 2008.
  19. Youth & tobacco. Centers for Disease Control and Prevention. http://www.cdc.gov/tobacco/youth/information_sheets/yuthfax1.htm. Accessed Oct. 27, 2008.
  20. Hurt RD (expert opinion). Mayo Clinic, Rochester, Minn. Nov. 5, 2008.

DS00307

Nov. 26, 2008

© 1998-2009 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Reliable tools for healthier lives," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

Print Share Reprints

Text Size: smaller largerlarger