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Definition
By Mayo Clinic staff
Squamous cell carcinoma (SCC) is the second most common form of nonmelanoma skin cancer following basal cell carcinoma.
Squamous cell carcinoma rarely causes further problems when caught and treated early. Untreated, squamous cell carcinoma can grow large or spread to other parts of your body, causing serious complications.
The incidence of skin cancers is rising every year, likely due to increased sun exposure. Most squamous cell carcinomas result from prolonged exposure to ultraviolet (UV) radiation, either from sunlight or from tanning beds or lamps. Avoiding UV light as much as possible is the best protection. Sunscreen is an important part of a sun-safety program, but by itself doesn't completely prevent squamous cell carcinoma or other types of skin cancer.
- Wood GS, et al. Nonmelanoma skin cancers: Basal cell and squamous cell carcinomas. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone; 2008. http://www.mdconsult.com/das/book/body/119479231-3/0/1709/83.html?tocnode=55017273&fromURL=83.html#4-u1.0-B978-0-443-06694-8..50078-6--cesec29_2759. Accessed Feb. 6, 2009.
- Squamous cell carcinoma. American Academy of Dermatology. http://www.aad.org/public/Publications/pamphlets/SquamousCellCarcinoma.htm. Accessed Feb. 6, 2009.
- Squamous cell carcinoma of the skin. National Cancer Institute. Accessed Feb. 6, 2009.
- Skin cancer prevention. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/prevention/skin/Patient/page2. Accessed Feb. 6, 2009.
- Detailed guide: Skin cancer - basal and squamous cell. American Cancer Society. Accessed Feb. 6, 2009.
- Ferri F. Squamous cell carcinoma. In: Ferri FF. Ferri's Clinical Advisor 2009. St. Louis, Mo.: Mosby; 2008. http://www.mdconsult.com/das/book/body/119479231-4/801716560/1417/447.html#4-u1.0-B978-0-323-04836-1..50007-1--cesec44_620. Accessed Feb. 9, 2009.
- Urist MM, et al. Melanoma and cutaneous malignancies. In: Townsend CM, et al. Townsend: Sabiston Textbook of Surgery. 18th ed. Philadelphia, Pa.: W.B. Saunders; 2007. http://www.mdconsult.com/das/book/body/119479231-5/0/1565/1.html?tocnode=54736195&fromURL=1.html#4-u1.0-B978-1-4160-3675-3..X5001-1--TOP_1. Accessed Feb. 6, 2009.
- Sunscreen. The Skin Cancer Foundation. http://www.skincancer.org/the-scfs-guide-to-sunscreens.html. Accessed Feb. 6, 2009.
- Arsenic toxicity exposure pathways. U.S. Department of Health and Human Services. http://www.atsdr.cdc.gov/csem/arsenic/exposure_pathways.html. Accessed Feb. 6, 2009.
- Ridky TW. Nonmelanoma skin cancer. Journal of the American Academy of Dermatology. 2007;57:484.
- Neoplasia. In: Kumar V, et al. Robbins and Cotran's Pathologic Basis of Disease. 7th ed. Philadelphia, Pa.: Saunders Elsevier; 2005. http://www.mdconsult.com/das/book/body/119515236-4/801835407/1249/66.html#4-u1.0-B0-7216-0187-1..50011-0--cesec92_600. Accessed Feb. 6, 2009.
- Premalignant and malignant nonmelanoma skin tumors. In: Habif TP. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 4th ed. New York, N.Y.: Mosby; 2004. http://www.mdconsult.com/das/book/body/119515236-5/0/1195/157.html?tocnode=51442435&fromURL=157.html#4-u1.0-B0-323-01319-8..50023-6_2588. Accessed Feb. 6, 2009.
- Common questions about diet and cancer. American Cancer Society. Accessed Feb. 6, 2009.
- Food Groups to Encourage. In: U.S. Department of Health and Human Services and U.S. Department of Agriculture. Dietary Guidelines for Americans. 6th Edition. Washington, D.C.: U.S. Government Printing Office; 2005. http://www.health.gov/DietaryGuidelines/dga2005/document/html/chapter5.htm. Accessed Feb 6, 2009.
